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Sildenafil + Tadalafil + Oxytocin (Compounded Combination)
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Sildenafil + Tadalafil + Oxytocin: Combined Blood Flow and Bonding Injection
Two PDE5 inhibitors plus the bonding hormone in one injection for reliable performance and emotional connection.
This compounded injection combines two PDE5 inhibitors (sildenafil and tadalafil) with oxytocin. The two PDE5 inhibitors approach blood flow from slightly different timeframes, which can broaden the window of effect. Oxytocin adds the emotional bonding dimension. This combination is at the prescriber’s discretion and is typically reserved for patients who haven’t fully responded to single-agent therapy.
Physician-prescribed · Compounded by licensed US pharmacies · Multi-pathway formula · Ongoing care team support
Sildenafil (PDE5 Inhibitor, fast-onset): Sildenafil typically takes effect within 30 to 60 minutes and lasts about 4 hours. It’s the same active ingredient as Viagra.
Tadalafil (PDE5 Inhibitor, long-acting): Tadalafil’s effects last up to 36 hours, making timing more flexible. It’s the same active ingredient as Cialis.
Oxytocin (Bonding Hormone): Oxytocin supports feelings of closeness and emotional engagement during intimacy.
Best for: Adults who haven’t responded fully to single-PDE5-inhibitor therapy and want broader timeframe coverage, with the added emotional bonding component of oxytocin.
Not recommended for: Anyone taking nitrates or certain alpha-blockers (dangerous interaction), those with significant cardiovascular disease, severe liver or kidney disease, recent stroke, pregnancy, or a history of priapism.
Most common side effects reflect the combined profile: headache, flushing, nasal congestion, back pain or muscle aches, and mild stomach discomfort. Rare but more serious: priapism (a prolonged painful erection requiring emergency care), significant blood pressure changes, sudden vision or hearing loss, and the cardiovascular risks of combining PDE5 inhibitors with nitrates.
¹ Sildenafil: 84% of men reported improved erections (100 mg) Goldstein I, Lue TF, Padma-Nathan H, et al. Oral sildenafil in the treatment of erectile dysfunction. New England Journal of Medicine, 1998;338(20):1397-1404. → NEJM · PubMed
² Tadalafil: effective for up to ~36 hours Porst H, Padma-Nathan H, Giuliano F, et al. Efficacy of tadalafil at 24 and 36 hours after dosing. Urology, 2003;62(1):121-125. → PubMed
³ Oxytocin: increased orgasm intensity and contentment after intimacy Behnia B, Heinrichs M, Bergmann W, et al. Differential effects of intranasal oxytocin on sexual experiences and partner interactions in couples. Hormones and Behavior, 2014;65(3):308-318. → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
Sildenafil + Tadalafil + Oxytocin (Compounded Combination) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
Each component has individual clinical support. Combined stacks are at the prescriber’s discretion and reflect compounded combination therapy rather than data from registrational trials of the combination. (Source: Hatzimouratidis et al., European Urology Supplements, 2015)
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
About 30 to 60 minutes before anticipated intimacy.
Sildenafil has a faster onset but a shorter window. Tadalafil has a slower onset but lasts much longer. The combination can broaden the window of effect.
PDE5 inhibitors address blood flow. Oxytocin addresses the emotional and bonding dimension that’s often part of full sexual response.
Yes. Baseline blood pressure, cardiovascular history, and a full medication review are required because PDE5 inhibitors interact dangerously with nitrates.
You won’t be charged for the medication.
No. Compounded combination products are paid out of pocket.
Yes, at any time before your next shipment, with no long-term commitment.
Initial check-in at 4 to 6 weeks, with ongoing access to your care team.
Seek emergency medical attention immediately. Priapism can cause permanent damage.
No. Use as prescribed for on-demand support. Daily PDE5 protocols use lower doses of tadalafil alone.
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