*Actual product packaging may differ from the image shown.
Sermorelin (Injectable)
Select size
Shop All Treatments
Sermorelin: Nightly Injection That Restores Your Body’s Own Growth Hormone
A physician-prescribed peptide that works with your pituitary, not around it, to address the hormonal decline that drives aging.
Sermorelin is a peptide injection taken at bedtime that prompts your pituitary to release more of your own growth hormone, the same hormone that drives muscle repair, fat metabolism, sleep quality, and cellular recovery, and that declines steadily after age 30. Rather than replacing growth hormone directly (as with synthetic HGH), sermorelin signals your body to produce its own, preserving the natural pulsatile rhythm and feedback loop that keeps levels in a physiologic range.
Physician-prescribed · Compounded by licensed US pharmacies · Calibrated to your IGF-1 · Ongoing care team support
Sermorelin (Growth Hormone-Releasing Hormone Analog): Sermorelin is a synthetic analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH), your body’s own signal to the pituitary to release growth hormone. When taken at bedtime, it amplifies your natural overnight GH pulse, leading to a measurable rise in IGF-1 (the downstream marker of growth hormone activity). Because sermorelin works upstream of the pituitary and is subject to your body’s normal negative feedback, the risk of supraphysiologic GH levels is substantially lower than with exogenous HGH.
Best for: Adults over 30 experiencing symptoms consistent with age-related GH decline (increased abdominal fat, reduced lean muscle despite training, poor sleep quality, slower recovery, declining energy) who have a low or low-normal IGF-1 on baseline labs.
Not recommended for: Anyone with active malignancy (GH and IGF-1 can promote tumor growth), those with a known pituitary tumor, pregnant or breastfeeding individuals, and patients with severe untreated hypothyroidism.
Sermorelin has a long-established safety profile and is generally well-tolerated. The most common side effects are injection-site reactions (redness, swelling, mild pain), flushing, and occasional headache. Most are mild and improve within the first weeks. Vivid dreams or changes in sleep patterns are also reported, often viewed positively by patients. Rare but more notable risks include water retention, joint stiffness, or symptoms of mildly elevated GH, all generally dose-dependent and reversible with adjustment.
¹ Raised IGF-1 by about 35% over 6 months in older adults Khorram O, Laughlin GA, Yen SS. Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. JCEM, 1997;82(5):1472-1479. → PubMed
² Increased lean body mass (about 1.3 kg in men) in a randomized trial Liu H, Bravata DM, Olkin I, et al. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Annals of Internal Medicine, 2007;146(2):104-115. (~2 kg fat-mass reduction and ~2 kg lean-mass gain with GH in healthy elderly, with notable adverse events and no functional improvement; sermorelin-specific large trials are limited.) → PubMed
³ Works with your own pituitary to support GH release Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clinical Interventions in Aging, 2006;1(4):307-308. (Large long-term efficacy RCTs in healthy adults are lacking. Compounded sermorelin is not FDA-approved; the prior product Geref was withdrawn in 2008.) → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
Sermorelin (Injectable) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
Sermorelin has been studied across more than three decades, with the strongest evidence in growth-hormone-deficient populations. In smaller adult trials, sermorelin therapy has restored IGF-1 to younger-adult ranges in older men and women, with associated improvements in lean body mass and sleep architecture. (Source: Walker, Clinical Interventions in Aging, 2006; Khorram et al., Journal of Clinical Endocrinology and Metabolism, 1997)
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
HGH replaces growth hormone directly. Sermorelin signals your pituitary to release more of your own, preserving the natural pulsatile rhythm and feedback loop. Most providers consider this a more physiologic approach.
Once nightly via subcutaneous injection, typically before bed and on an empty stomach. The timing matters because the dose amplifies your natural overnight GH pulse.
Sleep quality often improves within the first weeks. Body composition and recovery changes typically take 3 to 6 months and depend heavily on consistent training and nutrition.
No. Adult prescribing typically uses IGF-1 levels and clinical symptoms rather than a formal GHD diagnosis.
Baseline IGF-1 and a metabolic panel establish your starting point and confirm safety. Follow-up labs measure your response and inform dose adjustments.
You won’t be charged for the medication.
Generally no. Compounded peptides are paid out of pocket.
Yes, at any time before your next shipment, with no long-term commitment.
Retesting IGF-1 at 8 to 12 weeks, with ongoing check-ins at a recurring cadence.
Combination protocols are common in clinical practice. Any stacking is at your provider’s discretion based on your goals and labs.
Your GH levels return to your natural baseline. There is no withdrawal effect.
The next generation
of weight management.
Dual-incretin metabolic support — personalized to you.
