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Sermorelin + Glycine (Injectable)
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Sermorelin + Glycine: Nightly Injection for Growth Hormone Support and Deeper Sleep
Sermorelin’s pituitary support combined with glycine’s documented effects on sleep depth and recovery.
Sermorelin + Glycine is a compounded blend that pairs sermorelin’s pituitary-stimulating effect on your own growth hormone with glycine, an amino acid documented to improve sleep depth and next-day alertness. Because much of growth hormone release happens during deep sleep, supporting both pathways in one injection can produce a more pronounced effect on recovery, body composition, and cognitive freshness than sermorelin alone.
Physician-prescribed · Compounded by licensed US pharmacies · Combined sleep and GH support · Ongoing care team support
Sermorelin (Growth Hormone-Releasing Hormone Analog): Sermorelin is a synthetic analog of the first 29 amino acids of GHRH, your body’s own signal to the pituitary to release growth hormone. Taken at bedtime, it amplifies your natural overnight GH pulse, leading to a measurable rise in IGF-1. Because it works upstream of the pituitary and is subject to your body’s normal negative feedback, the risk of supraphysiologic GH levels is substantially lower than with exogenous HGH.
Glycine (Amino Acid for Sleep Depth): Glycine is a non-essential amino acid that acts as an inhibitory neurotransmitter and supports thermoregulation during sleep. Clinical studies have shown that glycine taken before bed improves subjective sleep quality, reduces sleep latency, and improves next-day cognitive performance, particularly in people with poor baseline sleep.
Best for: Adults over 30 who want growth hormone support paired with deeper sleep and faster recovery. Particularly well-suited for those whose sleep quality has declined and whose recovery between training sessions has slowed.
Not recommended for: Anyone with active malignancy (GH and IGF-1 can promote tumor growth), those with a known pituitary tumor, pregnant or breastfeeding individuals, and patients with severe untreated hypothyroidism.
Side effects mirror sermorelin alone: injection-site reactions, occasional flushing, headache, and vivid dreams. Glycine is generally very well tolerated, with rare reports of mild digestive symptoms.
¹ Raised IGF-1 by about 35% over 6 months in older adults Khorram O, Laughlin GA, Yen SS. Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. JCEM, 1997;82(5):1472-1479. → PubMed
² Increased lean body mass (about 1.3 kg in men) in a randomized trial Liu H, Bravata DM, Olkin I, et al. Systematic review: the safety and efficacy of growth hormone in the healthy elderly. Annals of Internal Medicine, 2007;146(2):104-115. → PubMed
³ Glycine and subjective sleep quality (small oral studies) Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in Neurology, 2012;3:61. (Oral glycine ~3 g before bed showed modest improvements in subjective sleep quality; injection-route data is essentially absent.) → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
Sermorelin + Glycine (Injectable) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
Sermorelin has been shown to raise IGF-1 to younger-adult ranges in older adults. Glycine taken at bedtime has been shown in controlled studies to improve subjective sleep quality and next-day performance. (Source: Walker, Clinical Interventions in Aging, 2006; Bannai & Kawai, Frontiers in Neurology, 2012)
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
Much of growth hormone release happens during deep sleep. Glycine supports deeper, more restorative sleep, which can amplify the effects of sermorelin on GH and IGF-1.
Once nightly before bed via subcutaneous injection.
Sleep quality often shifts within the first 1 to 2 weeks. Body composition and recovery changes typically take 3 to 6 months.
No. Adult prescribing uses IGF-1 and clinical symptoms rather than a formal GHD diagnosis.
Baseline IGF-1 and a metabolic panel establish your starting point and confirm safety.
You won’t be charged for the medication.
No. Compounded peptides are paid out of pocket.
Yes, at any time before your next shipment, with no long-term commitment.
IGF-1 retest at 8 to 12 weeks, with ongoing check-ins at a recurring cadence.
Your GH levels return to baseline. There is no withdrawal effect.
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