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NAD+ (Nasal Spray)
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NAD+ Nasal Spray: Coenzyme Support Without the Needle
A daily intranasal spray that delivers NAD+ directly across the nasal mucosa, no injection required.
NAD+ nasal spray is an intranasal form of nicotinamide adenine dinucleotide, the coenzyme your cells use to make energy and repair DNA. The nasal route bypasses the digestion that degrades oral NAD+, delivering the coenzyme directly across the nasal mucosa for systemic absorption and (with some evidence) direct delivery to the brain via the olfactory pathway. Most people use it for energy, focus, recovery, and the general anti-aging effects of supporting cellular NAD+ levels.
Physician-prescribed · Compounded by licensed US pharmacies · Needle-free delivery · Ongoing care team support
NAD+ (Nicotinamide Adenine Dinucleotide, intranasal): Intranasal delivery is well-studied as a route to bypass first-pass liver metabolism and to provide direct nose-to-brain transport for certain molecules. For NAD+, the route offers a needle-free way to support cellular energy and DNA repair pathways with the convenience of a once-daily spray.
Best for: Adults focused on longevity, cognitive performance, energy, and recovery who would prefer not to inject. Often a good fit for people who want the cognitive-focused benefits of NAD+ in particular.
Not recommended for: Anyone with active malignancy, pregnant or breastfeeding individuals, and people with chronic nasal conditions that may impair absorption.
Most common side effects are mild nasal irritation, transient burning sensation, and occasional headache, generally improving with consistent use. Systemic effects are less common than with injection but follow similar patterns when present (flushing, mild nausea).
¹ NAD+ is a cofactor in energy metabolism; tissue levels decline with age Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021;22(2):119-141. → PubMed
² Raising NAD+ is an active area of therapeutic research Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism, 2018;27(3):529-547. → PubMed
³ Administered NAD+ is taken up and used by the body A pharmacokinetic study confirmed that administered NAD+ raises circulating NAD+ and its metabolites. (Supporting context: Grant R, et al. Frontiers in Aging Neuroscience, 2019;11:257, an IV pharmacokinetic study.) → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
NAD+ (Nasal Spray) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
Intranasal delivery of small molecules and peptides is established for direct nose-to-brain transport and systemic uptake. Clinical evidence specifically for intranasal NAD+ is emerging and less robust than for injectable forms. (Source: Crowe et al., Drug Discovery Today, 2018)
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
Daily intranasal spray, typically one to two sprays per nostril. Your provider gives specific guidance.
Cognitive clarity often shifts within 1 to 2 weeks. Energy and recovery effects build over 4 to 8 weeks.
Same coenzyme. The nasal route is more convenient, with the trade-off that systemic absorption is generally lower than with subcutaneous injection.
Not typically required, though baseline markers can help tailor your protocol.
You won’t be charged for the medication.
Compounded NAD+ for longevity indications is paid out of pocket.
Yes, at any time before your next shipment, with no long-term commitment.
Initial check-in at 4 to 8 weeks, then on a recurring cadence.
Most irritation resolves with consistent use. If persistent, your provider may adjust the formulation.
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