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NAD+ (Injectable)
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NAD+: Injectable Coenzyme for Energy, Recovery, and Cellular Health
The molecule your cells need to make energy, taken as a weekly injection that bypasses digestion.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It’s central to how your mitochondria produce energy, how your DNA gets repaired, and how your cells respond to stress. NAD+ levels decline with age, and injectable NAD+ is one of the most direct ways to support those levels alongside lifestyle and other protocols. Most people describe a noticeable shift in energy, mental clarity, and recovery within the first weeks of consistent dosing.
Physician-prescribed · Compounded by licensed US pharmacies · Personalized dosing · Ongoing care team support
NAD+ (Nicotinamide Adenine Dinucleotide): NAD+ powers your mitochondria, the energy factories inside each cell. It’s also required by sirtuins and PARP enzymes, the proteins that maintain DNA integrity and regulate the cellular stress response. Direct injection avoids the absorption limitations of oral NAD precursors and delivers the coenzyme into circulation, where it gets taken up by tissues that need it most.
Best for: Adults focused on longevity, recovery, energy, and cognitive performance, particularly those over 35 who notice declining baseline energy, slower recovery from exercise, or reduced mental sharpness.
Not recommended for: Anyone with active malignancy (NAD+ supports cellular replication broadly), pregnant or breastfeeding individuals, and anyone with serious cardiovascular instability. Your provider reviews your full health history before prescribing.
Most common side effects are injection site discomfort, transient flushing, mild headache, and nausea during administration, especially with higher doses. These are typically dose-dependent and improve with slower injection. Less common but more notable considerations include the broad metabolic effect of raising NAD+ throughout the body, which is one reason NAD+ is not used during active cancer treatment.
¹ NAD+ is a cofactor in energy metabolism; tissue levels decline with age Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, 2021;22(2):119-141. → PubMed
² Daily NAD+ precursor supplementation raised blood NAD+ by about 60% in a randomized trial Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation elevates NAD+ in healthy middle-aged and older adults. Nature Communications, 2018;9(1):1286. → PubMed
³ Administered NAD+ is taken up and used by the body Grant R, Berg J, Mestayer R, et al. A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+. Frontiers in Aging Neuroscience, 2019;11:257. → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
NAD+ (Injectable) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
NAD+ precursors and direct supplementation have been shown to restore NAD+ levels in older adults, with associated improvements in markers of mitochondrial function and metabolic health in early trials. Direct intravenous and subcutaneous administration has been studied in smaller cohorts for fatigue, recovery, and cognitive endpoints. (Source: Martens et al., Nature Communications, 2018)
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
Subcutaneous injection, typically once or twice weekly. Your provider will guide on dose and pace.
Many people notice improved energy and clarity within the first 1 to 2 weeks. Recovery and sleep benefits often build over 4 to 8 weeks.
Oral NAD+ precursors get processed in the gut and liver before reaching tissues. Direct injection of NAD+ itself delivers the coenzyme into circulation more efficiently for systemic effect.
Not always required, but a baseline metabolic panel and inflammatory markers can help your provider tailor the protocol.
You won’t be charged for the medication.
Compounded NAD+ for longevity indications is paid out of pocket.
Yes, at any time before your next shipment, with no long-term commitment.
Check-ins at 4 to 8 weeks initially, then on a recurring cadence.
Slow the injection pace. Most people find slower delivery resolves these effects.
Often yes. Combination protocols are common. Any stacking is at your provider’s discretion.
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