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Minoxidil 5% / Finasteride / Tretinoin Spray
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Minoxidil 5% + Finasteride + Tretinoin Spray: Standard-Strength Triple-Active Topical
The most studied combination in topical hair loss therapy: minoxidil, topical finasteride, and tretinoin in one spray.
This compounded topical spray combines the three most-studied actives in topical hair loss therapy: standard 5% minoxidil, topical finasteride, and tretinoin. The combination is supported by more research than higher-strength or expanded formulas, and provides a strong starting point for most patients with pattern hair loss who haven’t yet tried compounded combination therapy.
Physician-prescribed · Compounded by licensed US pharmacies · Triple-active formula · Ongoing care team support
Minoxidil 5%: Minoxidil is a topical vasodilator that’s been used for hair loss for decades. It improves blood flow to follicles, extends the active growth phase of the hair cycle, and can stimulate dormant follicles. It works for both men and women and is typically applied once or twice daily to areas of thinning or loss. Five percent is the most studied concentration.
Topical Finasteride: Finasteride blocks the enzyme 5-alpha-reductase, which converts testosterone into DHT. DHT is the hormone primarily responsible for shrinking hair follicles in pattern hair loss. Lowering DHT lets follicles recover, slowing or stopping further loss and (for many men) supporting regrowth. Topical delivery reduces systemic absorption compared with the oral pill.
Tretinoin (Topical Retinoid): Tretinoin enhances minoxidil absorption and supports follicular turnover.
Best for: Adults with pattern hair loss starting on compounded combination topical therapy, or those who want strong evidence-based combination support without the higher-strength components.
Not recommended for: Pregnant or breastfeeding individuals (or anyone who may become pregnant), people with active scalp infections, and those allergic to any component.
Most common side effects are scalp irritation, redness, dryness, and itching, particularly during the first weeks. An initial shed in the first 4 to 8 weeks is normal. Topical finasteride may cause some of the same side effects as oral finasteride in a smaller proportion of users.
¹ 5% minoxidil significantly increases hair regrowth versus placebo Olsen EA, Dunlap FE, Funicella T, et al. A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men. Journal of the American Academy of Dermatology, 2002;47(3):377-385. → PubMed
² Tretinoin boosts minoxidil’s activation in the scalp Sharma A, Goren A, Dhurat R, et al. Tretinoin enhances minoxidil response in androgenetic alopecia patients by upregulating follicular sulfotransferase enzymes. Dermatologic Therapy, 2019;32(3):e12915. (Tretinoin upregulates the scalp sulfotransferase that converts minoxidil to its active metabolite.) → PubMed
³ About 90% of men maintained or improved hair over 5 years (finasteride) Finasteride Male Pattern Hair Loss Study Group. Long-term (5-year) experience with finasteride 1 mg in androgenetic alopecia. European Journal of Dermatology, 2002;12(1):38-49. (Oral finasteride; topical finasteride is not FDA-approved and is absorbed systemically.) → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
Minoxidil 5% / Finasteride / Tretinoin Spray is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
Minoxidil 5% is well established. Tretinoin co-application enhances minoxidil absorption. Topical finasteride has been shown to reduce scalp DHT with less systemic absorption than oral. The triple combination is supported by clinical experience and component-level evidence. (Source: Olsen, Journal of the American Academy of Dermatology, 2002; Caserini et al., Journal of Dermatological Treatment, 2016)
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
Once or twice daily to dry scalp, massaging gently into thinning areas.
It pairs the three most-studied actives in topical hair loss therapy: minoxidil for growth, finasteride for DHT, tretinoin for absorption and turnover.
Initial shedding in the first 4 to 8 weeks is normal. Visible regrowth typically takes 4 to 6 months.
Not typically required.
You won’t be charged for the medication.
No. Compounded topical formulas are paid out of pocket.
Yes, at any time before your next shipment, with no long-term commitment.
Initial check-in at 3 to 6 months to assess response, then on a recurring cadence.
Your provider may add adjuncts (oral finasteride, oral minoxidil), increase frequency, or recommend procedures like PRP or transplantation.
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