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Metformin (Injectable, Compounded)
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Metformin: Injectable Metabolic Support for Glucose Control and Longevity
The most-studied longevity medication, in an injectable form that bypasses gut absorption issues.
Metformin is a decades-old medication originally developed for type 2 diabetes and now widely prescribed off-label for metabolic health and longevity. It improves insulin sensitivity, lowers fasting glucose, and may have anti-aging effects through pathways involving AMPK and mTOR. The injectable form is used in cases where the oral version causes digestive issues that limit tolerability. Most people use metformin alongside other longevity protocols to address insulin resistance and metabolic flexibility.
Physician-prescribed · Compounded by licensed US pharmacies · Targeted dosing · Ongoing care team support
Metformin (Biguanide, AMPK activator): Metformin reduces glucose production by the liver, improves insulin sensitivity in muscle and other tissues, and activates AMPK, an enzyme involved in cellular energy sensing. The same pathways activated by caloric restriction and exercise are partially activated by metformin, which is one reason it’s been studied as a longevity intervention.
Best for: Adults with prediabetes, insulin resistance, polycystic ovary syndrome (PCOS), or those pursuing metabolic optimization as part of a longevity protocol who haven’t tolerated oral metformin.
Not recommended for: Anyone with significant kidney disease, severe liver disease, or active heart failure. Pregnant individuals should discuss carefully with their provider.
Most common side effects with metformin (mostly seen with oral forms) are nausea, diarrhea, and stomach discomfort, particularly during dose adjustments. The injectable form is used in part to minimize digestive symptoms. Rare but serious risks include lactic acidosis, especially in patients with kidney impairment or significant illness.
¹ 39% fewer heart attacks vs conventional treatment (overweight T2D) UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). The Lancet, 1998;352(9131):854-865. (Metformin reduced myocardial infarction by 39% and all-cause mortality by 36% vs conventional treatment. ORAL metformin.) → PubMed
² 31% lower risk of progressing from prediabetes to T2D Knowler WC, Barrett-Connor E, Fowler SE, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin (Diabetes Prevention Program). New England Journal of Medicine, 2002;346(6):393-403. (Metformin reduced T2D incidence by 31% vs placebo. ORAL metformin.) → NEJM · PubMed
³ HbA1c reduced by ~1 to 1.5 percentage points Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015 (ADA/EASD position statement). Diabetes Care, 2015;38(1):140-149. (Oral metformin monotherapy reduces HbA1c by ~1.0 to 1.5 percentage points.) → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
Metformin (Injectable, Compounded) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
Metformin has been shown across decades of clinical use to reduce HbA1c, improve insulin sensitivity, and reduce the risk of type 2 diabetes in prediabetic patients. Ongoing trials (such as TAME) are evaluating its effects on aging-related outcomes. (Source: DPP Research Group, New England Journal of Medicine, 2002)
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
Subcutaneous injection on a schedule your provider sets, typically several times weekly.
The injectable form is used primarily for patients who haven’t tolerated oral metformin’s digestive side effects.
Glucose markers shift within the first 4 to 12 weeks. Insulin sensitivity and metabolic effects build over months.
Yes. Baseline kidney function (eGFR), liver function, fasting glucose, and HbA1c are required.
You won’t be charged for the medication.
Compounded injectable metformin is typically paid out of pocket. Oral generic metformin is widely covered.
Yes, at any time before your next shipment, with no long-term commitment.
Labs at 12 weeks initially, then every 6 to 12 months once stable.
Metformin can reduce B12 absorption over time. Your provider may monitor and supplement if needed.
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