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GHK-Cu (Cream)
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GHK-Cu Cream: The Copper Peptide That Supports Your Skin's Own Repair
A gentle, daily copper-peptide cream that supports collagen, firmness, and the appearance of fine lines.
GHK-Cu cream is a cosmetic topical built around a naturally occurring copper peptide. GHK-Cu supports the skin's repair signaling, stimulating collagen, elastin, and glycosaminoglycans and supporting dermal fibroblasts. Because the peptide declines with age, replenishing it topically aims to support firmer, smoother-looking skin with gentle daily use.
Cosmetic-grade formulation · Prepared by licensed US pharmacies · Ongoing care team support
- GHK-Cu (Copper Tripeptide): A naturally occurring copper-binding peptide that stimulates collagen, elastin, and glycosaminoglycan synthesis and supports dermal fibroblasts, improving firmness and the appearance of fine lines while delivering copper for skin-repair enzymes.
Best for: Adults who want to support skin firmness and texture with a gentle, well-tolerated daily peptide, including those who find retinoids too irritating.
Not recommended for: Anyone with hypersensitivity to copper or peptide ingredients. This is a cosmetic product and is not intended to treat a medical skin condition.
GHK-Cu is generally well tolerated, with occasional mild redness or irritation at the application site and rare sensitivity to copper. Discontinue and consult a clinician if you develop a persistent rash. As a cosmetic product, it is not intended to treat medical skin conditions.
- ¹ Increased collagen production in about 70% of treated women Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences, 2018;19(7):1987 (PMID 29986520). (Reviews evidence that topical GHK-Cu improves aging-skin parameters; a comparison study found increased collagen in about 70% of treated women, versus 50% for vitamin C and 40% for retinoic acid.) → PubMed
- ² Stimulates collagen, elastin, and glycosaminoglycan synthesis and supports dermal fibroblasts Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International, 2015;2015:648108 (PMID 26236730). (GHK-Cu stimulates synthesis of collagen, dermatan and chondroitin sulfate, and decorin, and supports fibroblast function.) → PubMed
- ³ A naturally occurring copper peptide that declines with age and supports skin repair Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences, 2018;19(7):1987 (PMID 29986520). (GHK is naturally present in human plasma and declines with age; it supports blood vessel and nerve outgrowth and tissue repair.) → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
GHK-Cu (Cream) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
In a comparison study, topical GHK-Cu increased collagen production in about 70% of treated women, outperforming vitamin C and retinoic acid on that measure. Broader clinical and laboratory research shows GHK-Cu stimulates collagen, elastin, and glycosaminoglycan synthesis and supports fibroblasts. Effect sizes are moderate and results build over weeks.
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
Apply to clean skin twice daily as directed. It layers well under sunscreen and moisturizer.
Firmness and smoothness typically build over 8 to 12 weeks of consistent use.
Yes. Many people alternate or layer GHK-Cu with a retinoid; your care team can suggest a routine.
Adults wanting gentle collagen support, including those who cannot tolerate retinoids.
GHK-Cu is a cosmetic peptide; if you are pregnant or breastfeeding, check with your clinician before starting any new product.
Cosmetic creams are not covered by insurance; pricing is shared before you start.
Yes, at any time before your next shipment.
Your care team checks in on tolerance and results and can adjust your routine.
Reduce frequency and contact your care team; mild irritation usually resolves quickly.
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