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Estriol / GHK-Cu (Cream)
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Estriol / GHK-Cu Cream: Copper-Peptide Repair and Skin-Directed Estrogen
A compounded cream that pairs the regenerative copper peptide GHK-Cu with topical estriol to support firmer, smoother-looking skin.
Estriol / GHK-Cu cream is a compounded topical for aging skin that combines two dermal-support ingredients. GHK-Cu, a naturally occurring copper peptide, stimulates collagen and elastin and supports skin-repair signaling. Estriol, a weaker estrogen, supports the estrogen-responsive dermis that thins with age. Together they target firmness and the appearance of fine lines.
Physician-prescribed · Compounded by licensed US pharmacies · Ongoing care team support
- GHK-Cu (Copper Tripeptide): A naturally occurring peptide that stimulates collagen, elastin, and glycosaminoglycan synthesis and supports dermal fibroblasts, improving firmness and the look of fine lines.
- Estriol (Topical Estrogen): A weaker estrogen used topically to support collagen and fibroblast activity in estrogen-responsive skin. It is compounded and used off-label for skin.
Best for: Adults, particularly peri- and postmenopausal individuals, who want to support skin firmness and texture and prefer a gentler routine than a retinoid.
Not recommended for: Anyone pregnant, breastfeeding, or planning pregnancy; people with a history of estrogen-sensitive cancer or blood clots without specialist guidance; and those with hypersensitivity to the ingredients.
This cream is generally well tolerated, with occasional mild redness or irritation at the application site. Because estriol is an estrogen that can be absorbed, it is avoided in pregnancy and in people with estrogen-sensitive conditions. Discuss your history with your provider.
- ¹ Topical GHK-Cu increased collagen production in about 70% of treated women Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences, 2018;19(7):1987 (PMID 29986520). (Reviews evidence that topical GHK-Cu stimulates collagen, elastin, and glycosaminoglycan synthesis; a comparison study found increased collagen in about 70% of treated women.) → PubMed
- ² Topical estrogen stimulates collagen and thickens skin in postmenopausal women Topical estrogen therapy for aging skin: current evidence and clinical considerations. JAAD Reviews, 2025. (Small clinical trials of topical estrogens, including estriol, show collagen stimulation and epidermal thickening in postmenopausal skin; results are inconsistent.) → JAAD Reviews00103-5/fulltext)
- ³ Combines a collagen-supporting copper peptide with a skin-directed estrogen Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International, 2015;2015:648108 (PMID 26236730). (GHK-Cu modulates collagen and glycosaminoglycan synthesis and supports fibroblasts, complementing estrogen's dermal effects.) → PubMed
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
Estriol / GHK-Cu (Cream) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
Topical GHK-Cu has clinical and laboratory support for stimulating collagen and supporting dermal fibroblasts, with a comparison study showing increased collagen in about 70% of treated women. Small studies of topical estrogens show collagen stimulation and epidermal thickening in postmenopausal skin. The combination targets the dermis through complementary pathways.
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
Apply to clean skin twice daily as directed, or as advised by your provider.
Firmness and texture typically improve gradually over 8 to 12 weeks of consistent use.
GHK-Cu is generally gentler than retinoids, though mild irritation is possible.
Adults wanting dermal support, often peri- or postmenopausal. Your provider reviews your history, including estrogen-sensitive conditions.
No. Estrogens are avoided in pregnancy and breastfeeding.
Compounded cosmetic creams are generally not covered; pricing is shared before you start.
Yes, at any time before your next shipment.
Yes. Your care team checks in on tolerance and results.
Reduce frequency and contact your care team; mild irritation usually settles quickly.
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