*Actual product packaging may differ from the image shown.
Baclofen (Oral Tablet)
Shop All Treatments
Baclofen: Relief From Muscle Spasticity and Spasms
A prescription muscle relaxant that calms overactive nerve signals behind spasticity, dosed carefully and tapered when stopping.
Baclofen is a prescription skeletal-muscle relaxant used to reduce spasticity, muscle spasms, and related pain, most often from multiple sclerosis or spinal cord conditions. It works in the spinal cord as a GABA-B agonist, enhancing the body's inhibitory signals to relax overactive muscles. It is titrated up gradually and must be tapered rather than stopped suddenly.
Physician-prescribed · Dispensed by licensed US pharmacies · FDA-approved active ingredient · Ongoing care team support
- Baclofen (GABA-B Receptor Agonist): A centrally acting muscle relaxant that activates GABA-B receptors in the spinal cord, enhancing inhibitory signaling and reducing motor-neuron excitability to ease spasms, clonus, and stiffness.
Best for: Adults with spasticity from multiple sclerosis or spinal cord conditions who need to reduce painful spasms and stiffness, under physician guidance.
Not recommended for: People seeking relief for spasticity from stroke, cerebral palsy, or Parkinson disease (where efficacy is not established); those with significant kidney impairment without dose adjustment; and anyone with hypersensitivity to baclofen.
The most common effects are drowsiness, dizziness, and weakness, especially when starting or increasing the dose, and they are worsened by alcohol or other sedatives. The most important safety point is never to stop baclofen abruptly, because withdrawal can be severe and even life-threatening. People with reduced kidney function need lower doses to avoid toxicity.
- ¹ Effectively reduces muscle spasticity, spasms, and associated pain Baclofen. StatPearls. NCBI Bookshelf, 2023. (Baclofen effectively manages spasticity by relieving flexor spasms, clonus, and associated pain in conditions such as multiple sclerosis and spinal cord injury.) → NCBI Bookshelf
- ² FDA-approved for spasticity from multiple sclerosis and spinal cord conditions Baclofen (professional drug monograph). Drugs.com, 2026. (Oral baclofen is FDA-approved for management of spasticity and its sequelae from multiple sclerosis and other spinal cord lesions; efficacy is not established in stroke, cerebral palsy, or Parkinson disease.) → Drugs.com
- ³ A GABA-B agonist that calms overactive motor-nerve signaling Baclofen. StatPearls. NCBI Bookshelf, 2023. (Baclofen is a GABA-B receptor agonist that enhances inhibitory signaling in the spinal cord to reduce motor-neuron excitability and muscle spasticity.) → NCBI Bookshelf
How it Works With EHRX
The entire process is online. No waiting rooms. Just straightforward, medically guided care.
Step 1
Choose your treatment and complete checkout
You'll receive a confirmation email with next steps.
Step 2
Complete a brief medical consultation
Check your email for a link to a short intake form and link to a virtual consult with a licensed physician.
Step 3
A licensed provider reviews your consultation
If approved, your prescription is written and sent to the pharmacy. If not, you receive a full refund.
Step 4
Your pharmacy ships within 3–5 business days
Your medication is shipped directly to your door in temperature-controlled packaging.
What to know before you start.
Baclofen (Oral Tablet) is a compounded medication prepared by a licensed pharmacy for individual patient use.
It has not been reviewed by the FDA for safety or efficacy, and is prescribed based on the clinical judgment of a qualified healthcare provider. Compounded drugs are permitted to be prescribed but are not FDA-approved for safety and efficacy.
Clinical Evidence
Baclofen effectively reduces spasticity, including flexor spasms, clonus, and associated pain, and is one of the most commonly used oral antispasmodics. It has been FDA-approved for spasticity from multiple sclerosis and spinal cord lesions since 1977. Response and tolerability vary, and sedation can limit dosing.
Frequently Asked Questions
We aim to provide absolute clarity regarding your biological data and personalized wellness protocols.
Take baclofen by mouth as prescribed, usually in divided doses. Your provider increases the dose gradually to balance relief and drowsiness.
Some relief can come within days, with the best dose found over a few weeks of gradual adjustment.
No. Baclofen must be tapered under medical supervision; stopping suddenly can cause dangerous withdrawal.
People with kidney impairment, seizure disorders, or psychiatric conditions, and anyone who uses alcohol or other sedatives, should be evaluated first.
Efficacy is established for spasticity from multiple sclerosis and spinal cord conditions, not for stroke, cerebral palsy, or Parkinson disease.
Generic baclofen is widely available and inexpensive; coverage varies. Pricing is shared before you start.
Yes, at any time before your next shipment, but do not stop taking baclofen abruptly; taper under provider guidance.
Yes. Your care team adjusts the dose to your response and side effects and plans a taper if you stop.
Tell your care team; the dose or schedule can often be adjusted. Avoid alcohol and other sedatives.
The next generation
of weight management.
Dual-incretin metabolic support — personalized to you.
