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AOD-9604 / MOTS-C
AOD-9604 / MOTS-c is a complementary metabolic peptide combination designed to support fat loss, energy metabolism, and cellular efficiency. AOD-9604 targets fat metabolism by increasing fat breakdown and limiting new fat storage, while MOTS-c, a mitochondrial-derived peptide, helps improve metabolic flexibility and energy utilization at the cellular level. Together, this combination supports body composition, metabolic health, and long-term weight optimization, particularly for individuals looking to enhance fat loss while also supporting energy and mitochondrial function.
Protocols developed under the clinical direction of Dr. Jonathann Kuo, MD
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What happens after checkout
- ①Purchase your treatment
- ②Complete your Qualiphy consultation via email (~3 min)
- ③Licensed provider reviews & approves your prescription
- ④Pharmacy ships within 3–5 days of approval
After checkout, you'll receive an email to complete your telehealth consultation. A licensed provider must approve before your order ships.
Potential benefits may include:
- Promotes fat loss by increasing lipolysis and reducing fat storage.
- Supports mitochondrial function and cellular energy production.
- Improves metabolic efficiency and flexibility.
- Helps address stubborn or resistant fat areas.
- May support energy levels, endurance, and metabolic resilience.
- Complements nutrition, exercise, and other metabolic or peptide therapies.
- Pregnancy or Breastfeeding: Safety has not been established; use is not recommended.
- Active Cancer or Recent Cancer Treatment: Metabolic and growth-related peptides are generally avoided.
- Known Allergy: Avoid use if you have a sensitivity to peptide-based therapies or formulation components.
- Severe Liver or Kidney Disease: Should be used only under medical supervision.
- Mitochondrial or metabolic disorders: Use with provider guidance to ensure appropriate dosing and monitoring.
AOD-9604 / MOTS-c is generally well tolerated. Mild, short-term effects may occasionally occur, especially when first starting or adjusting dose, including:
- Temporary redness, tenderness, or itching at the injection site
- Mild headache or light fatigue as metabolism and mitochondrial signaling adjust
- Temporary changes in appetite or digestion
- Brief muscle warmth or mild flushing (more commonly associated with MOTS-c)
These effects are typically mild and resolve as the body adapts.
For safe and informed use, review the Extension Health Injection Reaction Guide (PDF), which outlines what to expect, how to reduce discomfort, and when to seek medical support.
- Weeks 1–2: AOD-9604 begins signaling fat cells to increase fat breakdown (lipolysis) and reduce new fat storage, while MOTS-c starts supporting mitochondrial energy production and metabolic flexibility. Early changes are primarily cellular, though some patients notice subtle shifts in energy, appetite awareness, or exercise tolerance.
- Weeks 3–6: As metabolic and mitochondrial signaling becomes more consistent, the body becomes more efficient at using both fat and glucose for fuel. Patients may begin to notice gradual improvements in body composition, energy levels, and workout recovery—especially when paired with nutrition and movement.
- Weeks 8–12: Sustained use supports ongoing fat utilization, mitochondrial efficiency, and metabolic resilience. Visible improvements in body composition, weight stability, and energy are more likely during this phase. Results tend to be steady and sustainable, making the AOD-9604 / MOTS-c combination well suited for long-term metabolic health and body composition support rather than rapid weight loss.