Semaglutide / B12

Semaglutide offers wide-ranging benefits that extend beyond weight loss by improving metabolic signaling, appetite regulation, and insulin sensitivity. Potential benefits may include:

• Supports sustainable weight loss by reducing appetite and increasing feelings of fullness.
• Improves blood sugar regulation and insulin sensitivity, helpful for insulin resistance and metabolic syndrome.
• Helps reduce cravings and compulsive eating behaviors, including sugar cravings.
• Promotes healthier fat metabolism when paired with proper nutrition and movement.
• Supports cardiovascular health by improving metabolic markers and reducing inflammation.
• Helps stabilize energy levels and mood by minimizing blood sugar fluctuations.
• May offer metabolic and longevity benefits even at lower, maintenance-focused doses.

• Pregnancy or Breastfeeding: Safety has not been established; use is not recommended.
• Personal or Family History of Medullary Thyroid Carcinoma: GLP-1 therapies are contraindicated.
• Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2): Increased risk of thyroid tumors.
• History of Pancreatitis or Severe Gastrointestinal Conditions (e.g., gastroparesis): Use only with provider guidance and careful monitoring.
• Known Allergy: Avoid use if you have a sensitivity to Semaglutide, B12, or formulation components.

Semaglutide is generally well tolerated when used under medical supervision. Short-term side effects may occur, particularly when first starting or adjusting dose, including:

• Nausea (most common), especially during early treatment or dose increases
• Diarrhea or loose stools
• Constipation as digestion slows
• Decreased appetite, which may feel abrupt early on
• Mild fatigue or headache as blood sugar and appetite signaling adjust
• Temporary redness, tenderness, or itching at the injection site

These effects are typically mild and improve as the body adapts. At Extension Health, we emphasize starting at a low dose and increasing gradually, as this approach significantly reduces side effects and allows your body to adjust at a pace that feels sustainable.

Regular provider check-ins are encouraged to assess tolerance, symptom response, and overall progress. Monitoring tools such as DEXA scans and bloodwork are also recommended to ensure adequate nutrition, preserve lean muscle mass, and support long-term metabolic health. Maintaining proper hydration and adequate protein intake while on a GLP-1, and incorporating supportive peptides (such as growth hormone options) or vitamins when appropriate, can further help optimize muscle preservation and body composition.

For safe and informed use, review the Extension Health Injection Reaction Guide (PDF), which outlines what to expect, how to reduce discomfort, and when to seek medical support.

• Days 1–7: Semaglutide begins activating GLP-1 receptors that regulate appetite, satiety, and blood sugar. Early effects often include reduced hunger, feeling full sooner, and fewer cravings. Weight changes are usually minimal at this stage as the body adjusts to new appetite signals.
• Weeks 2–4: As GLP-1 signaling stabilizes, appetite regulation becomes more consistent. Many patients notice improved portion control, steadier energy levels, and reduced cravings, especially for sugar or late-night snacking. This is when gradual, sustainable weight loss may begin for those using Semaglutide for weight management.
• Weeks 4–8 and Beyond: With continued, individualized use, patients may experience steady improvements in weight, metabolic health, insulin sensitivity, and inflammation. At Extension Health, we typically recommend aiming for 1–2 pounds of weight loss per week, as this rate supports fat loss while preserving muscle and metabolic health.

Importantly, everyone’s ideal dose is different. Some patients gradually increase dosing to support weight loss goals, while others remain at lower or micro-dose levels long-term to support metabolic health, inflammation reduction, hormone balance, and longevity—without significant weight loss. Semaglutide is highly adaptable, making it effective across a wide range of health goals when used thoughtfully and under provider guidance.