Placeholder product image

NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is a critical coenzyme found in every cell of the body that plays a central role in cellular energy production, DNA repair, and metabolic function. NAD+ levels naturally decline with age, stress, illness, and inflammation, which can impact energy, cognitive function, and overall resilience. Injectable NAD+ helps replenish these levels more efficiently, supporting mitochondrial function, cellular repair processes, and long-term vitality from the inside out.

Medical Grade99+ PurityMade in the USAFDA Certified Facility

Select Size:

Potential benefits may include:

  • Supports mitochondrial function and cellular energy production
  • Enhances DNA repair and cellular resilience
  • Improves energy levels and reduces fatigue
  • Supports cognitive clarity, focus, and brain health
  • Helps the body adapt to physical, mental, and oxidative stress
  • May support healthy aging and metabolic function
  • Pregnancy or Breastfeeding: Safety has not been established; use is not recommended.
  • Active Cancer or Recent Cancer Treatment: Cellular and metabolic support therapies are generally avoided unless specifically directed by a provider.
  • Known Allergy: Avoid use if you have a sensitivity to NAD+, niacin-related compounds, or formulation components.

Mild, short-term effects may occasionally occur, especially when first starting, including:

  • Temporary redness, tenderness, or itching at the injection site
  • A burning or stinging sensation during injection, which is common with NAD+ and typically resolves within minutes (this can be uncomfortable but is normal)
  • Flushing, warmth, or mild skin redness, similar to a niacin-like response
  • Mild headache, light fatigue, or dizziness as cellular energy pathways adjust
  • Temporary changes in appetite or energy levels

These effects are usually mild and resolve as the body adapts. Because NAD+ directly impacts mitochondrial and cellular energy metabolism, starting at a lower dose and gradually increasing is recommended to assess tolerance and minimize discomfort.

For safe and informed use, review the Extension Health Injection Reaction Guide (PDF), which outlines what to expect, how to reduce discomfort, and when to seek medical support.

  • Weeks 1–2: NAD+ begins replenishing intracellular levels of this essential coenzyme, supporting mitochondrial energy production, DNA repair, and cellular signaling. Some patients notice subtle improvements in mental clarity, energy consistency, or stress tolerance, as well as transient warmth or flushing shortly after injections.
  • Weeks 3–6: As NAD+ availability increases, cells become more efficient at producing energy and managing oxidative stress. Patients may begin to notice improvements in daytime energy, cognitive focus, sleep quality, and recovery, particularly when NAD+ is paired with hydration, nutrition, and adequate rest.
  • Weeks 8–12: With sustained use, NAD+ supports ongoing mitochondrial efficiency, cellular repair processes, and metabolic resilience. More noticeable improvements in overall vitality, fatigue resistance, cognitive performance, and stress adaptation may occur during this phase. While some effects are rapid and felt the day of injection, benefits also accumulate overtime, making NAD+ well suited for energy support, recovery, and long-term cellular health.